
癌症定制疫苗首度闖過III期
Merck與Moderna宣布,個性化腫瘤疫苗intismeran autogene在黑色素瘤III期試驗中取得陽性結果,與PD-1抑制劑聯用可顯著改善無復發生存期及無遠處轉移生存期。該療法利用患者腫瘤突變資料與AI篩選新生抗原,為每位患者製作專屬mRNA疫苗。
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Merck與Moderna宣布,個性化腫瘤疫苗intismeran autogene在黑色素瘤III期試驗中取得陽性結果,與PD-1抑制劑聯用可顯著改善無復發生存期及無遠處轉移生存期。該療法利用患者腫瘤突變資料與AI篩選新生抗原,為每位患者製作專屬mRNA疫苗。

Moderna and Merck reported that a personalized mRNA therapy, intismeran, combined with Keytruda met key recurrence and distant-metastasis survival endpoints in a prespecified interim analysis. The approach uses AI to select up to 34 tumor-specific neoantigens for an individually manufactured treatment.

GitLab 19.3 adds bulk SAST False Positive Detection and Agentic SAST Vulnerability Resolution for existing vulnerability backlogs. Teams can automatically assess findings, dismiss likely false positives, and generate ready-to-merge fixes, including for SARIF-imported third-party scanner results.

Amazon Bedrock AgentCore Web Search now supports per-request domain and publication-date filters. Developers can control which websites agents use and require fresher sources, with filtering enforced server-side.

KnowledgeForge converts resolved ITSM incident tickets into new knowledge base articles and continuously curates existing content. Its multi-tenant, closed-loop pipeline uses Amazon Bedrock, Amazon S3 Vectors, and AWS Step Functions for deduplication, quality scoring, and content improvement.

NVIDIA introduces Cosmos 3 Edge, a compact world model designed for on-device robot control. The 4B omni-model includes a 2B NVIDIA Nemotron-based reasoner to support adaptive policies across sensors, environments, and tasks.
Qwen Code v0.21.15 improves Web Shell performance, file attachments, sidebar synchronization, and Goal v3 controls. It also adds reasoning toggles for hybrid Qwen models, resume support for reviews, and authenticated HTTPS Git extension installs.

LangSmith Preview Builds allow teams to test pull request branches in temporary, production-like deployments before merging agent changes. This gives developers a safer way to validate behavior without affecting the main production environment.

AWS demonstrates how Amazon Bedrock can add context-aware security monitoring to healthcare FHIR APIs. The approach detects anomalous access patterns, classifies data sensitivity, and generates natural-language compliance reports without adding latency to clinical workflows.

Waymo has developed a custom chip designed to improve the performance of its robotaxis. The chip also reduces the company’s reliance on third-party suppliers such as Nvidia.